meRfi®-GM
Arthritis & T helper 17 cell (Th17)
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Haas and colleagues reported that lactate builds up in arthritic joints because of a Warburg-like metabolic process, particularly aerobic glycolysis, carried out by synovial fibroblasts. In this situation, synovial-infiltrating CD4+ T cells take in lactate through SLC5A12.
The uptake limits the movement of T cells, trapping them in the inflamed tissue. As a result, this process increases the levels of inflammatory cytokines, especially [interleukin (IL)-17](brain://gxTb-ttgjlqhmWcXTkFzYg/…