meRfi®-GM
Toll-like receptor 3 (TLR-3)
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Toll-Like Receptor 3 (TLR-3) is endosomal localized
Toll-Like Receptor 3 (TLR-3) is unique among Toll-Like Receptors (TLRs) as it does not activate via the MyD88 NFKB MAPK Signal transduction Pathway. Instead, it activates NFKB and Interferon (IFN) Regulatory Factor 3 (IRF3) through the TRIF-Dependent Pathway
Toll-Like Receptor 3 (TLR-3) engagement increases production of Interferons Type I (IFN Type I), [Chemokine (C-X-C motif) liga…
References (Sources)
- .01 Pattern recognition receptors: immune targets to enhance cancer immunotherapy
- Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies
- Recognition and signaling by Toll-like receptors
- TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer’s DiseaseReview
- Toll-like receptor 9 agonists as cancer therapeutic