meRfi®-GM
TRIF-Dependent Pathway
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TIR-Domain-Containing Adapter-Inducing Interferon-beta (TRIF) promotes the activation of both TNF receptor-associated Factor 6 (TRAF6) and RIP1, which activate Transforming growth factor-β-Activated Kinase 1 (TAK1), resulting in NFKB and AP-1 activity and the production of innate immune effector molecules. Additionally, TRIF-dependent signaling activates [TANK-binding kinase 1 (TBK1)](brain://mcjAPKoMU0…