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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

CD284 (Toll-Like Receptor 4 (TLR-4))

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It cooperates with LY96 (also referred as MD-2) and CD14 to mediate in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria.

.01 Pattern recognition receptors: immune targets to enhance cancer immunotherapy
Shekarian et al. 2017 Ann Oncol. 28(8): 1756-1766
Review
Activation of TLR4 signaling promotes gastric cancer progression by inducing mitochondrial ROS production
Yuan et al. 2013a Cell Death Dis. 4: e794
CD14 controls the LPS-induced endocytosis of Toll-like receptor 4
Zanoni et al. 2011 Cell 147: 868-880
CD74 and macrophage migration inhibitory factor as therapeutic targets in gastric cancer
Zheng et al. 2012 World J Gastroenterol. 18: 2253-61
Recognition and signaling by Toll-like receptors
West et al. 2006 Annu Rev Cell Dev Biol. 22: 409-37
Review
Targeting TLR4-dependent inflammation in post-hemorrhagic brain injury
Karimy et al. 2020 Expert Opinion on Therapeutic Targets 24: 525-533
Review
Toll‑like receptor 4 plays a tumor‑suppressive role in cutaneous squamous cell carcinoma
Mikami et al. 2019 Int. J. of Oncology 54: 2179-2188

2/26/2026