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Beta-glucuronidases & Xenobiotics biodegradation / Drug metabolism
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Studies looking at the bulk enzymatic activity of the gut microbiota have shown that bacterial beta-glucuronidases are involved in deconjugating xenobiotics in the gut, allowing them to be reabsorbed through the portal vein thus prolonging their time in the body.
One-quarter of the medications potentially metabolized by beta-glucuronidase are opioids, estrogens, NSAIDs, benzodiazepines, antihypertensives, and antidiabetics
see also:
Diclofenac & Gut microbiota
Gut microbiota & Indomethacin
Gut microbiota & Ketoprofen
…