Dendritic Cells (DCs) maturation

Maturation of Dendritic Cells (DCs) goes along with increased IL-12 production
Dong et al., 2010

The maturation of dendritic cells (DCs) is crucial for initiating immune responses.
Fujii et al. 2003

A single intravenous (i.v.) injection of Alfa-galactosylceramide (alfa-GalCer) induced full maturation of splenic DCs within 4 hours in mice. Maturation was evidenced by: Increased expression of costimulatory molecules and MHC class II / HLA class II human, Production of interferon-gamma (IFN-γ), enhanced stimulation of the mixed leukocyte reaction
Fujii et al. 2003

The changes in DCs were not directly induced by Alfa-galactosylceramide (alfa-GalCer). Natural killer T (NKT) cells were required for this process, acting independently of the MyD88 adaptor protein.
Fujii et al. 2003

This maturation is responsible for inducing combined Th1 CD4+ and CD8+ T cell immunity to a coadministered protein antigen.
Fujii et al. 2003

Imidazoquinoline molecules such as imiquimod and resiquimod directly induce pDC maturation as determined by cytokine induction, CCR7 and co-stimulatory marker expression and prolonging viability.
Gibson et al., 2002

Dendritic Cells (DCs) maturation is characterized by significant change in cell’s antigen expression pattern and functions.
Luft et al. 2002

CD40L potently induces dendritic cell (DC) maturation
Luft et al. 2002

Phagocytosis of apoptotic/ necrotic tumor cells resulted in maturation of Dendritic Cells (DCs).
Chen et al. 2001 Int J Cancer 93: 539-548

Mature DC can induce quiescent T cells to become activated.
Banchereau & Steinman, 1998

see also:
Dendritic Cells (DCs) & Gut microbiota