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The Peptidoglycan (PGN) synthesis enzyme MurA interacts directly and specifically with the Lipopolysaccharides (LPS) synthesis enzyme LpxC .
All gram-negative bacteria release outer membrane vesicles (OMVs) into the external milieu to deliver effector molecules that alter the host and facilitate virulence
This complex envelope presents a formidable barrier to drug entry and is a major determinant of the intrinsic [antibiotic resistance](brain…