meRfi®-GM
Gram-negative bacteria
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Contents
The Peptidoglycan (PGN) synthesis enzyme MurA interacts directly and specifically with the Lipopolysaccharides (LPS) synthesis enzyme LpxC .
All gram-negative bacteria release outer membrane vesicles (OMVs) into the external milieu to deliver effector molecules that alter the host and facilitate virulence
This complex envelope presents a formidable barrier to drug entry and is a major determinant of the intrinsic [antibiotic resistance](brain…
References (Sources)
- Coordination of bacterial cell wall and outer membrane biosynthesis
- Host immunity and cellular responses to bacterial outer membrane vesicles
- Outer Membrane Vesiculation Facilitates Surface Exchange and In Vivo Adaptation of Vibrio cholerae
- Permeability barrier of Gram-negative cell envelopes and approaches to bypass it
- The bacterial cell envelope