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Tumor-associated carbohydrates (TACA)
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Altered glycosylation is a common characteristic of tumor cells, leading to the formation of tumor-associated carbohydrates (TACA). In cancer, three common changes are often observed:
- increased expression of Incomplete glycans / Truncated glycans,
- increased branching of N-glycans, and
- an augmented or altered presence of sialic acid-containing glycans.
Tumor-associated carbohydrates (TACA) can act as [tumor-specific antigens](brain://gPmP_RZMhUeyvLAfDNXfqw/TumorspecificAntige…