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Branching of N-glycans
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Contents
Increased branching of N-glycans, mediated by beta-1,6-N-acetyl-glucosaminyltransferase V (MAGT5), can influence cell adhesion, migration, and metastasis of tumor cells.
Increased branching of N-glycans can directly inhibit T cell activation by increasing T cell receptor (TCR) clustering. This effect was attributed to interaction with [gale…
References (Sources)
- Control of T cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis
- Glycosylation Changes in Cancer.
- Glycosylation in the era of Cancer-Targeted therapy: where are we heading?
- Importance of membrane-proximal N-glycosylation on integrin β1 in its activation and complex formation
- Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation
- Suppression of tumor growth and metastasis in Mgat5-deficient mice