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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

RAR-related orphan receptor gamma/t (ROR-gamma/t) Isoform 2 (NR1F3)

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Master regulator of T helper 17 cell differentiation
Ivanov et al. 2006 Cell 126: 1121-33

The transcription factor RAR-related orphan receptor gamma/t (ROR-gamma/t) Isoform 2 (NR1F3) is required for the differentiation of all IL-22 producing immune cell subsets (e.g., T helper 17 cell (Th17), Gamma Delta T Cells, and group 3 innate lymphoid cells (ILC3)) (Brooks II & Hooper 2020). The expression of [RAR-related orphan…

Interactions among microbes, the immune system, and the circadian clock
Brooks II & Hooper 2020
Review
Microbial Flora Drives IL-22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense
Satoh-Takayama et al. 2008 Immunity 29: 958
Progressive loss of RORγt expression confers distinct functional fates to natural killer cell receptor-expressing RORγt+ innate lymphocytes
Vonarbourg et al. 2010
RORgamma/t protein modifications and IL17-mediated inflammation
Kumar et al. 2021b Trends in Immunology 42: 1037
Review
RORγt is crucial for gut homeostasis by regulating the expression of HB-EGF rather than IL-22 in activated ILC3s
Li et al. 2025 Cell Reports 44: 115793
Th17 cell differentiation is regulated by the circadian clock
Yu et al. 2013a Science 342: 727-730
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
Ivanov et al. 2006 Cell 126: 1121-33

12/16/2025