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Immune escape
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Contents
The accumulation of immunosuppressive cell populations within the tumor microenvironment (TME), such as myeloid-derived suppressor cells (MDSC), tumor-associated macrophages (TAM), and regulatory T cells (Treg), contributes to the development of immune escape
The number of predicted MHC Class I-associated neoantigens was correlated with cytolytic activity and was lower than expected in colorectal and other tumors, suggesting immune-mediated elimination
Mut…
References (Sources)
- Immune Escape during Breast Tumor Progression
- Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T cell function to promote tumoral immune escape
- Molecular & Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity
- New mutations raise specter of ‘immune escape’
- The determinants of tumour immunogenicity
- The Functional Crosstalk between Myeloid-Derived Suppressor Cells and Regulatory T Cells within the Immunosuppressive Tumor Microenvironment