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Myeloid-Derived Suppressor Cells (MDSCs)
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Contents
Myeloid suppressor cells (MDSCs) are a heterogeneous population of pathologically activated, mainly immature immunosuppressive myeloid cells.
Myeloid suppressor cells (MDSCs) arise in chronic inflammation, especially in late-stage cancer. Activation signals lead to different cell states in myeloid populations, leading to different suppressive modes.
Myeloid-Derived Suppressor Cells (MDSCs) induce immunosuppression. Treg depletion induces MDSC recruitment
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References (Sources)
- B-Glucan enhances antitumor immune responses by regulating differentiation and function of monocytic myeloid-derived suppressor cells
- Heat shock and HSP-70 regulate 5-FU- mediated caspase-1 activation in myeloid-derived suppressor cells and tumor growth in mice
- MDSC: Markers, development, states, and unaddressed complexity
- Myeloid-Derived Suppressor Cells and Radiotherapy
- Myeloid-Derived Suppressor Cells: A Propitious Road to Clinic
- PD-L1 targeting high-affinity NK (t-haNK) cells induce direct antitumor effect and target suppressive MDSC populations