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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Immunosuppression

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T-cell exhaustion, MDSCs, and Treg cells are important sources of immunosuppression in patients with protracted infections, including sepsis.
Hotchkiss & Opal 2020 N Engl J Med 382: 1270-1272

Organ transplant patients maintained on immune suppressive drugs are threefold to eightfold more likely to develop cancer.
Ostrand-Rosenberg 2008

Immunosuppressive mechanisms in non-tumor cells

The immunosuppressive mechanisms that are contributed by non-tumor cells include [Regulatory T Cells (Tregs)](brain://dMyb2MZhrUav…

References (Sources)

A galectin-3 ligand corrects the impaired function of human CD4 and CD8 tumorinfiltrating lymphocytes and favors tumor rejection in mice
Demotte et al. 2010 Cancer Res. 70: 7476-7488
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
Uyttenhove et al. 2003 Nature Med. 9: 1269-1274
Immune Surveillance: A Balance between Protumor and Antitumor Immunity
Ostrand-Rosenberg 2008
Myeloid-derived suppressor cells as regulators of the immune system
Gabrilovich et al. 2009 Nature Rev. Immunol. 9: 162-174
Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome
Gobert et al. 2009 Cancer Res. 69: 2000-2009
Reversal of tumoral immune resistance by inhibition of tryptophan 2,3 dioxygenase
Pilotte et al. 2012 Proc. Natl Acad. Sci. USA 109: 2497-2502
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
Curiel et al. 2004 Nature Med. 10: 942-949

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Immunosuppression - Wikipedia