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Immunosuppression
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Contents
T-cell exhaustion, MDSCs, and Treg cells are important sources of immunosuppression in patients with protracted infections, including sepsis.
Organ transplant patients maintained on immune suppressive drugs are threefold to eightfold more likely to develop cancer.
Immunosuppressive mechanisms in non-tumor cells
The immunosuppressive mechanisms that are contributed by non-tumor cells include [Regulatory T Cells (Tregs)](brain://dMyb2MZhrUav…
References (Sources)
- A galectin-3 ligand corrects the impaired function of human CD4 and CD8 tumorinfiltrating lymphocytes and favors tumor rejection in mice
- Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
- Immune Surveillance: A Balance between Protumor and Antitumor Immunity
- Myeloid-derived suppressor cells as regulators of the immune system
- Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome
- Reversal of tumoral immune resistance by inhibition of tryptophan 2,3 dioxygenase
- Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival