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A biofilm comprises any syntrophic consortium of microorganisms in which cells stick to each other and often also to a surface
In extreme environments, bacteria can form a biofilm to enhance their survival. The bacterial biofilm may serve as a bioshield for therapeutic proteins against stomach acid.
There appears to be a biofilm segmentation clock that organizes cell differentiation in space and time
The antimicrobial peptides produced by Paneth cells in intestine have long been investigated as an antibiofilm agent
Biofilms in the compromised intestinal tract protect pathogenic bacteria against host immune response
Biofilms Are Difficult to Eradicate because They Exhibit Resistance to Antimicrobial Treatments and Removal by Host Immune Systems. Bacterial biofilms are crucial in the Pathogenesis of Many Clinically Important Infections
A crucial biofilm extracellular polymeric substances (EPS) component is e.g., beta-1,6-N-acetyl-D-glucosamine
Engineered Bacteriophage should express a biofilm-degrading enzyme during infection
Engineered enzymatic phage substantially reduced bacterial biofilm cell counts by ab. 4.5 orders of magnitude (ab. 99.997% removal)
see also:
Pathogenic Bacteria