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Paneth Cells
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Small intestinal Paneth cells, residing at the crypt base, have a lifespan of about 3–6 weeks.
Paneth cells secrete a variety of antibacterial substances, such as antimicrobial peptides and Regenerating Islet-Derived Protein 3 Gamma / Regenerating Islet-Derived Protein III-Gamma (REG3G). The antibacterial substances and secretory IgA are secreted into mucus to protect against commensal pathogens
Liu et al…
References (Sources)
- Decreased secretion of Paneth cell α-defensins in graft-versus-host disease
- Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells
- Paneth cells: maestros of the small intestinal crypts
- Signaling pathways in intestinal development and cancer
- Surface components and metabolites of probiotics for regulation of intestinal epithelial barrierReview
- The intestinal epithelium tuft cells: specification and function
- γδ IEL effector API5 masks genetic susceptibility to Paneth cell death