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Cadherins are generally considered to negatively regulate Wnt signaling by sequestering beta-catenin at the cell membrane, reducing its availability for nuclear signaling
Cadherins can modulate Wnt signaling through interactions with Wnt coreceptors like LRP5/6, promoting beta-catenin degradation and reducing Wnt signaling. However, proteolytic cleavage of cadherins can release beta-catenin into the cytosol, enhancing Wnt signaling
Activation of the beta-catenin signaling pathway can …