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Mucins
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Mucins are biosynthesized, glycosylated, and stored in goblet cells
Mucins are heavily O-glycosylated , but can also be N-glycosylated , albeit much more sparsely
Lee et al. 2022 Journal of Microbiology 60(2) 215-223
Mucins produced by secretory goblet cells form the Mucosa / Mucous membrane and protect the underlying epithelial cells by physically shielding them from the luminal bolus
Targeting host [mucin glycans](brain://Hii5amc…
References (Sources)
- A mucin-responsive hybrid two-component system controls Bacteroides thetaiotaomicron colonization and gut homeostasis
- Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice
- Immunological aspects of intestinal mucus and mucins.
- Intestinal mucin is a chaperone of multivalent copper
- Prebiotics and other microbial substrates for gut functionality
- Roles of the Cell Surface Architecture of Bacteroides and Bifidobacterium in the Gut Colonization
- Structure and Function of the Cell Surface (Tethered) MucinsReview