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Th17 cells are implicated in neuroinflammation and cognitive impairment. Examples include multiple sclerosis, ischemic brain injury, and Alzheimer's disease.
In experiments with colitis mice, Th17 cells filter into the brain depending on the severity of colitis. This shows a connection between neuroinflammation and colitis.
Th17 cells have the ROR gamma/t transcription factor.
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