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Each bacterium triggers a specific T cell program. Germ-free mice lack certain T cells. Colonization with Candidatus Savagella (Segmented filamentous bacteria/SFB) or Clostridium species changes this. SFB leads to CD4+ Th17 cells differentiation. Clostridium affects Inducible / Peripheral Regulatory T Cells (iTregs / pTregs)
In the large intestine, Helicobacter hepaticus triggers …