meRfi®-GM
Cancer microbiome / Tumor microbiome & Colorectal cancer (CRC)
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Contents
Intracellular bacteria are present in various solid tumors, but their effects are not well understood. Research shows that Campylobacter is significantly enriched in primary colorectal cancer (CRC) lesions in patients with metastasis. The Campylobacter jejuni-derived cytolethal distending toxin (CDT) promotes CRC metastasis through JAK2-STAT3-MMP9 signaling, as observed in liver and pulmonary metastatic mouse models, and confirmed in infected human colonic tissue and CDT-treated tumoroids. The genotoxin CdtB is essential for the p…
References (Sources)
- A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects
- Adenoma-linked barrier defects and microbial products drive IL-23/ IL-17-mediated tumor growth
- Co-occurrence of anaerobic bacteria in colorectal carcinomas
- Colorectal cancer mutational profiles correlate with defined microbial communities in the tumor microenvironment
- Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation
- The cancer chemotherapeutic 5-fluorouracil is a potent Fusobacterium nucleatum inhibitor and its activity is modified by intratumoral microbiota
- The microbial landscape of colorectal cancer