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Neutrophil extracellular traps (NETs)
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Contents
Increased neutrophil extracellular trap (NET) formation and abundant NET-associated proteins are frequently found in the inflamed colon of patients with inflammatory bowel disease
Peptidyl arginine deiminase 4 (PAD4) activation is essential for generating Neutrophil extracellular traps (NETs) and NET-mediated pathogenesis.
The PAD4-mediated NET formation has a detrimental role in acute colitis
Lai et al. 2023 Inflammatory Bowel Diseases 29(5): 783-7…
References (Sources)
- Histones of Neutrophil Extracellular Traps Directly Disrupt the Permeability and Integrity of the Intestinal Epithelial Barrier
- Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates
- Increased dietary manganese impairs neutrophil extracellular trap formation rendering neutrophils ineffective at combating Staphylococcus aureus
- Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus
- Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis
- Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens
- Nuclease expression by Staphylococcus aureus facilitates escape from neutrophil extracellular traps