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IL-22–producing T cells can strongly and continuously activate enterocytes because they are located right next to them. However, it’s not exactly known how T cells help IECs or which epithelial cell groups are affected. It's also not clear why Citrobacter rodentium infection only happens in the mid to distal part of the large intestine.
There is a specific type of cell in the colon. These cells are only in the middle to end part of the colon. Citrob…