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Citrobacter rodentium
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IL-22–producing T cells can strongly and continuously activate enterocytes because they are located right next to them. However, it’s not exactly known how T cells help IECs or which epithelial cell groups are affected. It's also not clear why Citrobacter rodentium infection only happens in the mid to distal part of the large intestine.
There is a specific type of cell in the colon. These cells are only in the middle to end part of the colon. Citrob…
References (Sources)
- A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts
- Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22
- Citrobacter rodentium infection in mice elicits a mucosal Th1 cytokine response and lesions similar to those in murine inflammatory bowel disease
- IL-22 fate reporter reveals origin and control of IL-22 production in homeostasis and infection
- T Follicular Helper Cells Regulate Humoral Response for Host Protection against Intestinal Citrobacter rodentium Infection
- Th17 cell induction by adhesion of microbes to intestinal epithelial cells
- Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria