Leucine-Rich Repeats (LRRs) (C-terminal)

= an evolutionarily conserved protein motif composed of 2–45 stretches of the amino acid leucine, each repeat being 20–29 amino acids long.

Leucine-Rich Repeats (LRRs) (C-terminal) are frequently used to sense bacterial components (1, 2, 3), thus raising the possibility that bacteria directly activate the inflammasome.

References

(1) Martinon & Tschopp 2004 Cell 117: 561-574
(2) Martinon et al. 2002 Mol Cell 10: 417-426
(3) Mariathasan et al. 2004 Nature 430: 213-218

see also:
NLRP3 Inflammasome