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Triacylglycerols store metabolic energy in organisms and have industrial uses as foods and fuels. Excessive accumulation of triacylglycerols in humans causes obesity and is associated with metabolic diseases
Fatty acids (FAs) are the principal components of triacylglycerols found in oils and fats, which are the second primary source of dietary energy for humans
Triacylglycerol synthesis is catalysed by acyl CoA:diacylglycerol acyltransferase enzymes, the structures and catalytic mechanisms of wh…