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Cancer cells modify Tryptophan utilization to aid their survival and growth. Tryptophan metabolism is linked to immune suppression. Manipulating Tryptophan pathways can influence therapy responses.
Indoleamine 2,3-Dioxygenase (IDO) is an enzyme that catalyzes the degradation of tryptophan into kynurenine. This Kynurenine pathway is often upr…