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Indoleamine 2,3-Dioxygenase (IDO)
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Indoleamine 2,3-Dioxygenase (IDO) plays a crucial role in regulating immune cell function through the kynurenine pathway. It also depletes tryptophan in microenvironments, particularly in tumors, which has led to the development of IDO1 (indoleamine 2,3-dioxygenase1) inhibitors for cancer therapy. However, the connections between tryptophan depletion and product supply remain an ongoing challenge in cellular biochemistry and metabolism.
Fiore & Murray 2021 Current Opinion Immunology 70: 7-14
A tumoral immune resistance mechanism based on tryptophan degradation by [indoleamine …
References (Sources)
- Animal models of tumor immunity, immunotherapy & cancer vaccines
- Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR
- Crystal structure of human indoleamine2,3-dioxygenase: Catalytic mechanism of O2incorporation by a heme-containing dioxygenase
- Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
- IDO1 expression in ovarian cancer induces PD-1 in T cells via aryl hydrocarbon receptor activation
- Indoleamine 2,3-dioxygenase 1 (IDO1): an up-to-date overview of an eclectic immunoregulatory enzyme
- The blockade of immune checkpoints in cancer immunotherapyReview