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Cancer / Tumors & Tryptophan
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Contents
Cancer cells modify Tryptophan utilization to aid their survival and growth. Tryptophan metabolism is linked to immune suppression. Manipulating Tryptophan pathways can influence therapy responses.
Indoleamine 2,3-Dioxygenase (IDO) is an enzyme that catalyzes the degradation of tryptophan into kynurenine. This Kynurenine pathway is often upr…
References (Sources)
- Interactions of IDO and the Kynurenine Pathway with Cell Transduction Systems and Metabolism at the Inflammation-Cancer Interface
- New insights into tryptophan metabolism in cancer
- Tryptophan catabolites along the indoleamine 2,3-dioxygenase pathway as a biological link between depression and cancer
- Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes