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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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AuthorsReferences (Sources)

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Type VI secretion system (T6SS)

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Antimicrobial proteins play a crucial role as bypass mechanisms in bacteria. An essential aspect of this is the presence of genes encoding Type VI (T6) secretion systems in many human gut microbiomes. These systems facilitate contact-dependent transfer of effectors between bacteria.
Russell et al. 2014a Cell Host Microbe 16: 227–36
Chatzidaki-Livanis et al. 2016 Proc Natl Acad Sci USA 113: 3627-3632
Coyne et al. 2016 BMC Genomics 17: 58
Wexler et al. 2016 Proc Natl Acad Sci USA 113: 3639-3644
Bao et al. 2022 J Bacteriol 204: e0012222

The bacterial type VI secretion system (T6SS) is a protein secretion tool. It is found in many [Gram-negative bacteria](brain://…

References (Sources)

Analysis of Effector and Immunity Proteins of the GA2 Type VI Secretion Systems of Gut Bacteroidales
Bao et al. 2022 J Bacteriol 204: e0012222
Human symbionts inject and neutralize antibacterial toxins to persist in the gut
Wexler et al. 2016 Proc Natl Acad Sci USA 113: 3639-3644
The bacterial type VI secretion machine: yet another player for protein transport across membranes
Filloux et al. 2008 Microbiology (Reading, England) 154: 1570-1583
Review
The Type VI Secretion System in Enteric Pathogen Colonization: Molecular Mechanisms, Ecological Dynamics, and Therapeutic Potential
Sui & Qiao 2026 Front Microbiol 17: 1809019
Review
The type VI secretion toolkit
Cascales 2008 EMBO reports 9: 735-741
Review
Type VI secretion systems of human gut Bacteroidales segregate into three genetic architectures, two of which are contained on mobile genetic elements
Coyne et al. 2016 BMC Genomics 17: 58
Type VI secretion: a beginner’s guide
Bingle et al. 2008 Current opinion in microbiology 11: 3-8

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Type VI secretion system - Wikipedia