meRfi®-GM
Tr1 Treg
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Contents
Markers: CD4 +, CD49b +, LAG-3 +, CD226 + FOXP3 -
Type 1 Regulatory T Cells (Tr1) can also act in a contact-independent manner by elaborating soluble immunosuppressive factors, such as TGF- beta and IL-10
Type 1 Regulatory T Cells (Tr1) are IL-10 secreting cells
Tr1 cells inhibit Th reactivity via IL-10 and [TGF-beta](brain://0HQPXyRXdkGdJCNrmGbUFw/TransformingGrowthFactorBe…
References (Sources)
- Advances on Non-CD4 + Foxp3+ T Regulatory Cells: CD8+, Type 1, and Double Negative T Regulatory Cells in Organ Transplantation
- CD8+CD28− T suppressor cells and the induction of antigen-specific, antigen-presenting cell-mediated suppression of Th reactivity
- Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25 + CD4 + Tr cells
- FOXP3 + regulatory T cells in the human immune system