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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Tr1 Treg

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Markers: CD4 +, CD49b +, LAG-3 +, CD226 + FOXP3 -

Type 1 Regulatory T Cells (Tr1) can also act in a contact-independent manner by elaborating soluble immunosuppressive factors, such as TGF- beta and IL-10
Ligocki & Niederkorn 2015

Type 1 Regulatory T Cells (Tr1) are IL-10 secreting cells
Sakaguchi et al. 2010 Nature 10: 490

Tr1 cells inhibit Th reactivity via IL-10 and [TGF-beta](brain://0HQPXyRXdkGdJCNrmGbUFw/TransformingGrowthFactorBe…

Advances on Non-CD4 + Foxp3+ T Regulatory Cells: CD8+, Type 1, and Double Negative T Regulatory Cells in Organ Transplantation
Ligocki & Niederkorn 2015
Review
CD8+CD28− T suppressor cells and the induction of antigen-specific, antigen-presenting cell-mediated suppression of Th reactivity
Cortesini et al. 2001 Immunol Rev. 182: 201-206
Review
Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25 + CD4 + Tr cells
Levings et al. 2005 Blood 105: 1162-1169
FOXP3 + regulatory T cells in the human immune system
Sakaguchi et al. 2010 Nature 10: 490
Review

12/17/2025