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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Ferroptosis

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Ferroptosis can be induced in various ways. These include Gpx4 deletion, S100A4 inhibition, and cancer nanovaccines. These methods improve the tumor microenvironment. They work well with immune checkpoint inhibitors. This is seen in liver cancer and melanoma models
Cheu et al. 2023 Cell Mol Gastroenterol Hepatol 16: 133-159
Conche et al. 2023 Gut 72: 1774-1782
Li et al 2023 Sci Transl Med 15: eadg3049
Ma et al. 2023 Biomater Sci 11: 518-532

Ferroptosis shows necrotic morphology. It is similar to necroptosis. Both can trigger immune responses. They are types of immunogenic cell death.
Aaes et al. 2016 Cell Rep 15: 274-287
Kroemer et al. 2022 Nat Immunol 23: 487-500

CD8+ T lymphocytes mediate ferroptosis. Their cel…

References (Sources)

Apoptotic caspases suppress mtDNAinduced STING-mediated type I IFN production
White et al. 2014 Cell 159: 1549-1562
CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4
Liao et al. 2022 Cancer Cell 40: 365-378
CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy
Wang et al. 2019a Nature 569: 270-274
Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade
Conche et al. 2023 Gut 72: 1774-1782
Ferroptosis: an iron-dependent form of nonapoptotic cell death
Dixon et al. 2012 Cell 149: 1060-1072
Immunogenic cell stress and death
Kroemer et al. 2022 Nat Immunol 23: 487-500
Review
Vaccination with early ferroptotic cancer cells induces efﬁcient antitumor immunity
Eﬁmova et al. 2020 J Immunother Cancer 8: e001369

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Ferroptosis - Wikipedia