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Enterochromaffin Cells (EC) & Serotonin (5-HT)
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Contents
Enterochromaffin Cells (EC) cells act as chemosensors on the intestinal epithelium. They translate environmental stimuli into the production of serotonin (5-HT)
Enterochromaffin Cells (EC) recognize Interleukin-33 (IL-33) and release Serotonin (5-HT). Interleukin-33 (IL-33)-mediated release of Serotonin (5-HT) activates enteric neurons and subsequently promotes intestinal motility. For example, the immediate peristaltic movement facilitates the expulsion of [Trichuris muris…
References (Sources)
- 5-Hydroxytryptamine (serotonin) in the gastrointestinal tract
- A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release
- Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways
- Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis
- Serotonin Signaling in the Gastrointestinal Tract: Functions, dysfunctions, and therapeutic targets
- The chemical coding of 5-hydroxytryptamine containing enteroendocrine cells in the mouse gastrointestinal tract
- The Serotonin Neurotransmitter Modulates Virulence of Enteric Pathogens