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Interleukin-33 (IL-33)
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Contents
Transcription factor 7 (T-cell specific, HMG-box) (TCF7) expressing CD8+ T cells can self-renew like stem cells, a key for immune defense against chronic viral infections and cancer. A decisive factor for this property is interleukin-33 (IL-33).
Interleukin-33 (IL-33), part of the Interleukin-1 (IL-1) / Interleukin-1 family, is crucial for driving protective CD8+ T cell responses against v…
References (Sources)
- Fibroblast-derived IL-33 is dispensable for lymph node homeostasis but critical for CD8 + T-cell responses to acute and chronic viral infection
- IL-33 augments virus-specific memory T cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccine
- IL-33 in T cell differentiation, function, and immune homeostasis
- IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8 + T cells
- Interleukin-33 reinvigorates antiviral function of viral-specific CD8 + T Cells in Chronic Hepatitis B Virus Infection
- Overview of the IL-1 family in innate inflammation and acquired immunity
- Replicating viral vector platform exploits alarmin signals for potent CD8(+) T cellmediated tumour immunotherapy