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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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AuthorsReferences (Sources)

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Transcription factor 7 (T-cell specific, HMG-box) (TCF7)

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Transcription factor 7 (T-cell specific, HMG-box) (TCF7) is expressed in naive and memory T cells, playing a crucial role in T cell differentiation and maintenance. TCF7+ stem-like CD8+ T cells (CD8+ SL) are vital for sustaining T cell populations during chronic antigen exposure. The immune response to chronic viral infections is sustained by memory-like CD8(+) T cells that express Transcription factor 7 (T-cell specific, HMG-box) (TCF7).

These cells can differentiate into cytolytic cells lack…

References (Sources)

Cross-priming of CD8 + T cells stimulated by virus-induced type I interferon
Le Bon et al. 2003 Nat Immunol 4: 1009-1015
CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles(+) follicular cytotoxic T cells control viral infection in B cell follicles
Leong et al. 2016 Nat. Immunol. 17: 11871196
Differences in the transduction of canonical Wnt signals demarcate effector and memory CD8 + T cells with distinct recall proliferation capacity
Boudousquié et al. 2014 J Immunol 193: 2784-2791
Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy
Siddiqui et al. 2019 Immunity 50: 195–211
T cell factor 1-expressing memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections
Utzschneider et al. 2016 Immunity 45: 415–427
TCF1+ hepatitis C virus-speciﬁc CD8+ T cells are maintained after cessation of chronic antigen stimulation
Wieland et al. 2017 Nat. Commun. 8: 15050
Type-I IFN drives the differentiation of short-lived effector CD8 +T cells in vivo
Wiesel et al. 2012 Eur J Immunol 42: 320-329

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TCF7 - Wikipedia