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Transcription factor 7 (T-cell specific, HMG-box) (TCF7)
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Transcription factor 7 (T-cell specific, HMG-box) (TCF7) is expressed in naive and memory T cells, playing a crucial role in T cell differentiation and maintenance. TCF7+ stem-like CD8+ T cells (CD8+ SL) are vital for sustaining T cell populations during chronic antigen exposure. The immune response to chronic viral infections is sustained by memory-like CD8(+) T cells that express Transcription factor 7 (T-cell specific, HMG-box) (TCF7).
These cells can differentiate into cytolytic cells lack…
References (Sources)
- Cross-priming of CD8 + T cells stimulated by virus-induced type I interferon
- CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles(+) follicular cytotoxic T cells control viral infection in B cell follicles
- Differences in the transduction of canonical Wnt signals demarcate effector and memory CD8 + T cells with distinct recall proliferation capacity
- Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy
- T cell factor 1-expressing memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections
- TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation
- Type-I IFN drives the differentiation of short-lived effector CD8 +T cells in vivo