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Stem-like CD8+ T cells (CD8+SL)
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Contents
= a subset of CD8+ T-Cell / Cytotoxic T Cell (CTL)
He et al. 2016 Nature 537: 412–428
(20)
Marx et al. 2023 Immunity 56: 813–828
TCF1 / HNF1 homeobox A (HNF1A) expression marks stem-like CD8+ T cells (CD8+SL)
Stem-like CD8+ T cells (CD8+SL) express SLAM family member 6 (SLAMF6) (encoded by the [Slamf6 gene](brain://rkuDrpuDbUScwytvSIw…
References (Sources)
- CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles(+) follicular cytotoxic T cells control viral infection in B cell follicles
- Defining CD8 + T cells that provide the proliferative burst after PD-1 therapy
- Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy
- T cell factor 1-expressing memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections
- TCF1 expression marks self-renewing human CD8+(+) T cells
- TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation
- The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness