meRfi®-GM
The Digital Textbook on Gut Microbiota and Beyond
T cell differentiation
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Germ-free mice typically possess a limited number of intestinal T helper (Th)17 cells and Helios-negative peripheral (p) Treg cells. However, when these mice are colonized with segmented filamentous bacteria (SFB), there is a differentiation into T helper 17 cell (Th17). Similarly, colonization with a consortium of spore-forming Clostridium species leads to the differentiation of peripheral Treg cells (i.e., [RAR-related Orphan Receptor Gamma/T (ROR-gamma/t) Isoform 2 (NR1F3)t+ Foxp3+ Colonic Treg cells](br…