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The Interleukin-1 (IL-1) / Interleukin-1 family consists of 11 distinct members which are comprised of seven immunomodulatory cytokines, Interleukin-1 (IL-1) alfa / IL-1F1, Interleukin-1 (IL-1) beta (IL-1F2), Interleukin-18 (IL-18), Interleukin-36 (IL-36), Interleukin-33 (IL-33), and four Natural Interleukin-1 (IL-1) Family Antagonists (Interleukin-1 receptor antagonists (IL-1 Ra) / IL-1F3, Interleukin-36 Receptor Antagonist (IL-36 Ra) / IL-1F5, Interleukin-37 Receptor Antagonist (IL-37 Ra), Interleukin-38 Receptor Antagonist (IL-38 Ra))
Interleukin-1 (IL-1) / Interleukin-1 family is produced in: Monocytes, macrophages, lymphocytes, neutrophils, keratinocytes, microglia, megakaryocytes, fibroblasts, synovial lining cells, DCs, Endothelial Cells / Endothelium, smooth muscle cells
Interleukin-1 (IL-1) is a pleiotropic cytokine. It promotes immune responses against self antigens.
Interleukin-1 (IL-1) together with IL-23 can elicit lL-17 secretion by activated CD4+ and CD8+ T cells
Activation of Langerhans cells & dermal DCs increases expression of IL-1, IL-6, IL-12
IL-1 is required f expression of receptors for IL-2