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The Interleukin-1 (IL-1) / Interleukin-1 family consists of 11 distinct members which are comprised of seven immunomodulatory cytokines, Interleukin-1 (IL-1) alfa / IL-1F1, Interleukin-1 (IL-1) beta (IL-1F2), Interleukin-18 (IL-18), Interleukin-36 (IL-36), Interleukin-33 (IL-33), and four Natural Interleukin-1 (IL-1) Family Antagonists ([Inte…