meRfi®-GM
Macrophages (CD68s)
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To maintain and regulate intestinal homeostasis, the gut is equipped with one of the largest populations of macrophages in the body
Experiments in mice have shown that Intestinal macrophages are continuously replenished by peripheral monocytes in a CCR2-dependent manner (6)
Abraham et al. 2022 Gastroenterology 162: 1602-1616
Macrophages undergo profound metabolic reprogramming upon sensing infectious and sterile stimuli
However, macrophage polari…
References (Sources)
- Fibroblast-macrophage reciprocal interactions in health, fibrosis, and cancer
- Macrophage biology in development, homeostasis and disease
- Macrophages in health and disease
- Macrophages in the gut: Masters in multitasking
- Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology
- TLR-dependent T cell activation in autoimmunityReview
- Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancerReview