Enterochromaffin Cells (EC) & Serotonin (5-HT)

Enterochromaffin Cells (EC) cells act as chemosensors on the intestinal epithelium. They translate environmental stimuli into the production of serotonin (5-HT)
Chen et al. 2021 Immunity 54: 151-163

Enterochromaffin Cells (EC) recognize Interleukin-33 (IL-33) and release Serotonin (5-HT). Interleukin-33 (IL-33)-mediated release of Serotonin (5-HT) activates enteric neurons and subsequently promotes intestinal motility. For example, the immediate peristaltic movement facilitates the expulsion of Trichuris muris
Chen et al. 2021 Immunity 54: 151-163

Mechanistically, Interleukin-33 (IL-33) triggers calcium influx in Enterochromaffin Cells (EC) via a noncanonical signaling pathway to induce Serotonin (5-HT) secretion
Chen et al. 2021 Immunity 54: 151-163

Serotonin is synthesized by Enterochromaffin Cells (EC) by the enzyme Tryptophan hydroxylase 1 (TpH1). Upon its synthesis, serotonin is released into the lamina propria and is also secreted into the lumen and subsequently removed by the serotonin transporter SERT
Kumar et al. 2020c

Enterochromaffin Cells (EC) are a particular serotonin-producing enteroendocrine cell type thought to be crucial for conveying luminal information to the ENS
Mawe & Hoffman 2013 Nat Rev Gastroenterol Hepatol 10(8): 473-486
Bellono et al. 2017 Cell 170(1): 185-198
Alcaino et al. 2018 Proc Natl Acad Sci 115(32): E7632

Enterochromaffin cell-derived 5-hydroxytryptamine promotes liver regeneration
Gershon 2013 Curr. Opin. Endocrinol. Diabetes, Obes 20: 14-21

see also:
Interleukin-33 (IL-33)