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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Antibiotic tolerance

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Contents

Antibiotic tolerance allows temporary survival without growth in lethal antibiotic doses, characterized by slower killing rates without resistance. Both persistence and tolerance are linked to bacterial physiology and environment, with potential molecular determinants. These mechanisms, alongside genetic resistance, contribute to persistent infections.
Shah et al. 2006 BMC Microbiol. 6: 53
Maisonneuve & Gerdes 2014 Cell 157: 539-548
Schumacher et al. 2015 Nature 524: 59-64
Wu et al. 2015 Front. Microbiol. 6: 1003
Van den Bergh et al. 2016 Nat. Microbiol. 1: 16020
Erickson et al. 2017 ACS Synth. Biol. 6: 2302–2315
Balaban et al. 2019 Nat. Rev. Microbiol. 17: 441–448

see also:
Antibiotics & Pathogenic Bacteria
[Antibiotic persistence](brain://bB7…

References (Sources)

Deﬁnitions and guidelines for research on antibiotic persistence
Balaban et al. 2019 Nat. Rev. Microbiol. 17: 441–448
Distinguishing between resistance, tolerance and persistence to antibiotic treatment
Brauner et al. 2016 Nat. Rev. Microbiol. 14: 320-330
HipBA–promoter structures reveal the basis of heritable multidrug tolerance
Schumacher et al. 2015 Nature 524: 59-64
Molecular Mechanisms Underlying Bacterial Persisters
Maisonneuve & Gerdes 2014 Cell 157: 539-548
Review
Persisters: a distinct physiological state of E. coli
Shah et al. 2006 BMC Microbiol. 6: 53
Ranking of persister genes in the same Escherichia coli genetic background demonstrates varying importance of individual persister genes in tolerance to different antibiotics
Wu et al. 2015 Front. Microbiol. 6: 1003
Tolerance to antibiotics affects response
Berti & Hirsch 2020 Science 367: 141-142

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