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Both persistence and tolerance, which we collectively refer to as “recalcitrance,” are associated with treatment failure but are less well-studied than resistance due to the lack of appropriate tools and good experimental models.
Recalcitrant bacteria are transiently growth-inhibitory cells that can survive killing by multiple classes of antibiotics at concentrations that should be lethal.
The eventual resumption of growth by recalcitrant bacteria likely contributes to infection relapses.
We also used the [N. go…