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Antibiotics & Pathogenic Bacteria
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Both persistence and tolerance, which we collectively refer to as “recalcitrance,” are associated with treatment failure but are less well-studied than resistance due to the lack of appropriate tools and good experimental models.
Recalcitrant bacteria are transiently growth-inhibitory cells that can survive killing by multiple classes of antibiotics at concentrations that should be lethal.
The eventual resumption of growth by recalcitrant bacteria likely contributes to infection relapses.
We also used the [N. go…
References (Sources)
- Antimicrobial Resistance Profiles of Human Commensal Neisseria Species
- Definitions and guidelines for research on antibiotic persistence
- Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella
- Host stress drives tolerance and persistence: The bane of anti-microbial therapeutics
- Iron uptake from lactoferrin and transferrin by Neisseria gonorrhoeae
- Microbiota-mediated colonization resistance against intestinal pathogens
- The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens