Exometabolome

The exometabolome refers to the entire collection or set of all exometabolites present in the extracellular environment at a given time
Zha & Punt 2013 Metabolites 3(1): 119-43
Chugh et al. 2025 Trends in Microbiology 33(5): 546

The exometabolome refers to the complete set of metabolites that are secreted or released by an organism into its surrounding environment
Douglas 2020 Phil Trans R Soc B 375: 20190250

These extracellular metabolites, also known as exometabolites, form a unique chemical "footprint" that reflects the metabolic activities of cells, tissues, or entire microbial communities
Douglas 2020 Phil Trans R Soc B 375: 20190250
Harden et al. 2021 Front Cell Dev Biol 9: 626619

In bacteria, extracellular metabolites differ among species. Growth conditions and host environments affect the exometabolome
Mapelli et al. 2008 Trends Biotechnol 26: 490-497
Heim et al. 2020 Nat Microbiol 5: 1271-1284
Douglas 2020 Phil Trans R Soc B 375: 20190250

By utilizing environmental nutrients for growth and energy production, bacteria not only sustain themselves but also influence their surroundings through the release of metabolites. This dynamic process of nutrient uptake and metabolite release modifies the composition of the metabolic footprint, known as the exometabolome. The exometabolome represents the collection of metabolites present in the extracellular space, reflecting the interactions between the bacteria and their environment.
Kell et al. 2005 Nat Rev Microbiol 3: 557-565

In yeast, the exometabolome is linked to its phenotype
Allen et al. 2003 Nat Biotechnol 21: 692-696

see also:
Bacterial metabolites / Microbial metabolites
Exometabolites
Pathogenic Bacteria