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Creeping fat (CrF) is linked to surgical recurrence in Crohn’s disease.
Metabolome analysis shows L-kynurenine is enriched in Creeping Fat (CrF). Indoleamine 2,3-Dioxygenase (IDO) upregulation boosts kynurenine metabolism. This drives mesenteric adipogenesis.
L-kynurenine-induced adipogenesis is mediated by aryl hydrocarbon receptors. [IDO1 (indoleamine 2,3-dioxygenase1) inhibitors](brain://6zOG2wnEsUSiWcqUbbAqXg/Ido1Indoleamine23dioxygenase1In…