G-Protein Coupled Receptor 41 (GPR41)

G-Protein Coupled Receptor 41 (GPR41) is expressed by
• Enterocytes / Intestinal Epithelial Cells (IECs)
• Immune cells
• enteroendocrine L cells in the gut epithelium
to produce several effects that might impact liver metabolism.

Loss of G-Protein Coupled Receptor 41 (GPR41) signaling and decreased serum levels of PYY promote intestinal peristalsis and reduce energy procurement from food
Zhi et al. 2019 European Journal of Clinical Microbiology & Infectious Diseases 38: 1987-1998

Human G-Protein Coupled Receptor 41 (GPR41) exhibits greater affinity toward butyrate and propionate
Tang & Offermanns 2017 Handb Exp Pharmacol 236: 205–220

G-Protein Coupled Receptor 41 (GPR41) is expressed by a subset of enteroendocrine cells (i.e., L cells)
Samuel et al. 2008 PNAS 105: 16767-16772

G-Protein Coupled Receptor 41 (GPR41) is related to G-Protein Coupled Receptor 43 (GPR43) (52% similarity; 43% identity) and was activated by similar ligands but with differing specificity for carbon chain length, with pentanoate being the most potent agonist.
Brown et al. 2003 J. Biol. Chem. 278: 11312-11319

G-Protein Coupled Receptor 41 (GPR41) was expressed primarily in adipose tissue
Brown et al. 2003 J. Biol. Chem. 278: 11312-11319

G-Protein Coupled Receptor 41 (GPR41) expression appeared more widespread, with significant and grossly similar expression in spleen, lymph node, bone marrow, and PBMC
Le Poul et al. 2003

see also:
Enteroendocine Cell & G-Protein Coupled Receptor 41 (GPR41)