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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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AuthorsReferences (Sources)

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Coeliac / Celiac disease (CeD) & Gut microbiota

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The role of gut microbiota in the pathogenesis and management of Coeliac / Celiac disease (CeD) has been increasingly recognized.
Girdhar et al. 2023 Microbiome 11: 9
Rossi et al. 2023 Cells 12(6): 823

HLA-DQ2.5-mediated celiac disease (CeD) is triggered by gluten ingestion. HLA-DQ2.5 is gliadin-reactive. Gliadin-reactive T cells involved in Coeliac / Celiac disease (CeD) pathogenesis cross-react with ubiquitous bacterial peptides, suggesting microbial exposure as a potential environmental factor in Coeliac / Celiac disease (CeD).
Petersen et al. 2020 Nat Struct Mol Biol 27: 49-61

Research has indicated that …

References (Sources)

Altered duodenal microbiota composition in celiac disease patients suffering from persistent symptoms on a long-term gluten-free diet
Wacklin et al. 2014 Am J Gastroenterol 109(12): 1933-1941
Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation
Lamas et al. 2020 Sci Transl Med 12(566): eaba0624
Duodenal Bacteria From Patients With Celiac Disease and Healthy Subjects Distinctly Affect Gluten Breakdown and Immunogenicity
Caminero et al. 2016 Gastroenterology 151(4): 670-83
Dynamics of the gut microbiome, IgA response, and plasma metabolome in the development of pediatric celiac disease
Girdhar et al. 2023 Microbiome 11: 9
Interaction between Gut Microbiota and Celiac Disease: From Pathogenesis to Treatment. Cells
Rossi et al. 2023 Cells 12(6): 823
T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease
Petersen et al. 2020 Nat Struct Mol Biol 27: 49-61

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