meRfi®-GM
Cadherins / Cadherin
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The classic cadherins (E, N and P-) are concentrated at the intermediate cell junctions, which link to the network through specific linking proteins called Catenins / Catenin
Cadherins are a large family of calcium-dependent cell adhesion glycoproteins, each composed of five extracellular repeat domains (EC1-EC5), a transmembrane domain, and a highly conserved cytoplasmic tail that binds other cytoplasmic components including beta-catenin
Gumbiner 2005 Nat Rev Mol Cell Bio…