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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Butyrate / Butyric acid & Indoleamine 2,3-Dioxygenase (IDO)

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It decreases Signal transducer and activator of transcription 1 (STAT1) expression, thereby inhibiting the IFN-g-dependent, STAT1-driven transcription of IDO-1, and

it acts as a histone deacetylase (HDAC) inhibitor, which also reduces IDO-1 transcription independently of the STAT1 signal.
Th…

Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells
Martin-Gallausiaux et al. 2018 Front Immunol 9: 2838
Engineering bacteria for cancer immunotherapy by inhibiting IDO activity and reprogramming CD8+ T cell response
Wang et al. 2024 Proc Natl Acad Sci USA 121(52): e2412070121
Gut bacterium Intestinimonas butyriciproducens improves host metabolic health: evidence from cohort and animal intervention studies
Rampanelli et al. 2025 Microbiome 13(1): 15

5/29/2026