meRfi®-GM
Retinoic Acid (RA) (all-trans-retinoic acid)
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One active metabolite of vitamin A, RA, not only enhances the visual process and neurogenesis, but also drastically impacts immune responses and has great therapeutic potential in autoimmune diseases (Erkelens & Mebius 2017 Trends Immunol 38(3): 168-80; Saari 2016 Subcell Biochem 81: 231-59; Dumetz et al. 2020 Neurobiol Aging 85: 1-10; Hall et al. 2011a Immunity 34(3): 435-47). Migratory dendritic cells (DCs) convert vitamin A to RA in the mouse epithelial tissues, including the intestine, skin, lung, as well as in the associated draining lymph nodes (Guilliams et al. 2010 Blood 115(10): 1958-68)
Retinoic acid (RA) regulates gene expression by binding to several families of nuclear …