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Exclusive enteral nutrition (EEN) is a first-line therapy for pediatric Crohn's disease (CD). It generates temporally and individually variable microbiome profiles and induces remission in patients with pediatric Crohn's disease. Medium-chain fatty acids (lauric acid, Decanoic acid, and Octanoic acid) in the EEN are associated with protective changes in the microbiota of CD patients. Lachnospiraceae are also identified as protective features. They are significantly enriched in…