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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Takeda G-protein-coupled Receptor 5 (TGR5, BG37, GBPAR1) Agonists

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Desired effects of TGR5 agonists are increased Energy expenditure, GLP-1 secretion, and inhibition of inflammation
Li & Chiang 2020 Hepatobiliary Surg. Nutr. 9: 152-169

Therefore, clinical applications in obesity, type 2 diabetes, NASH, and atherosclerosis are conceivable
Li & Chiang 2020 Hepatobilia…

A G Protein-coupled Receptor Responsive to Bile Acids
Kawamata et al. 2003 J. Biol. Chem. 278: 9435–9440
Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1
Katsuma et al. 2005 Biochem Biophys Res Commun 329(1): 386-90
FXR and TGR5 Agonists Ameliorate Liver Injury, Steatosis, and Inﬂammation After Binge or Prolonged Alcohol Feeding in Mice
Iracheta-Vellve et al. 2018 Hepatol. Commun. 2: 1379-1391
Identiﬁcation of membrane-type receptor for bile acids (M-BAR).
Maruyama et al. 2002 Biochem. Biophys. Res. Commun. 298: 714-719
Interactions between bile salts, gut microbiota, and hepatic innate immunity
Schubert et al. 2017 Immunological Reviews 279: 23-35
Review
Manipulation of epithelial integrity and mucosal immunity by host and microbiota-derived metabolites
Kayama & Takeda 2020
TGR5-mediated bile acid sensing controls glucose homeostasis
Thomas et al. 2009 Cell Metab 10:167-77

5/29/2026